Arginase as a mediator of diabetic retinopathy
نویسندگان
چکیده
منابع مشابه
Arginase as a Mediator of Diabetic Retinopathy
We have shown previously that diabetes causes increases in retinal arginase activity that are associated with impairment of endothelial cell (EC)-dependent vasodilation and increased formation of the peroxynitrite biomarker nitrotyrosine. Arginase blockade normalizes vasodilation responses and reduces nitrotyrosine formation, suggesting that overactive arginase contributes to diabetic retinopat...
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The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and ...
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I AM very conscious of the fact that, being an ophthalmologist, I have only a superficial knowledge of diabetes mellitus and also that, not being associated with a diabetic clinic, I have had only limited opportunities of studying its retinal complications. Any observations I make will, therefore, be open to the criticism that they would not form the basis of a statistical analysis. For these s...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2013
ISSN: 1664-3224
DOI: 10.3389/fimmu.2013.00173